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Bionanosurf is an interdisciplinary team of researchers with expertise in physics, biochemistry, chemistry and biotechnology. The multi-disciplinary nature of our members facilitates research and development in many areas, including biosensors, gene therapy, magnetism, photochemistry, surface chemistry and molecular metal oxides, among others. As a collective, we have a vast amount of experience in the synthesis and characterization of novel nanomaterials and their subsequent biofunctionalization for the use and development of next generation nanobiosensors and nanotherapeutics. One of the keys to our success to date is that we actively collaborate with groups worldwide in order to expand our horizons and maximize the chances of applying our novel synthetic methodologies to real-world issues, most specifically in the field of medicine.


Our research lines are:


Molecular diagnosis and biosensors: we are focused on finding new biomarkers for the detection and monitoring of cancer treatments, as well as on the search of new transduction systems and new molecular imaging techniques using nanoparticles as core element.


Nanotherapeutics conjugates and drug delivery systems: our research focuses on the development of advanced therapies, particularly against cancer and tuberculosis, based on the rational design of new multifunctional nanoconjugates. These nanoconjugates consist of the incorporation of biomolecules able to vectorize these nanoparticles, active biomolecules focused on antitumoral drugs and antibiotics, and more complex active biomolecules as siRNA. We are working on new therapies using the physical properties of gold and magnetic nanoparticles to be used as tumor drugs delivery systems and ablation (optic or thermal).


Featured Publications
Alfranca, G., Beola, L., Liu, Y., Gutiérrez, L., Zhang, A., Artiga, A., … & de la Fuente, J. M. (2019). In vivo comparison of the biodistribution and long-term fate of colloids–gold nanoprisms and nanorods–with minimum surface modification. Nanomedicine, 14(23), 3035-3055

Moros, M., Idiago-López, J., Asín, L., Moreno-Antolín, E., Beola, L., Grazú, V., … & de la Fuente, J. M. (2019). Triggering antitumoural drug release and gene expression by magnetic hyperthermia. Advanced drug delivery reviews, 138, 326-343.

Gutiérrez, L., Moros, M., Mazario, E., de Bernardo, S., de la Fuente, J. M., del Puerto Morales, M., & Salas, G. (2019). Aggregation effects on the magnetic properties of iron oxide colloids. Nanotechnology.

Beola, L., Asín, L., Fratila, R. M., Herrero, V., de la Fuente, J. M., Grazú, V., & Gutiérrez, L. (2018). Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models. ACS applied materials & interfaces, 10(51), 44301-44313.

Stepien, G., Moros, M., Pérez-Hernández, M., Monge, M., Gutiérrez, L., Fratila, R. M., … & Pardo, J. (2018). Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in vivo. ACS applied materials & interfaces, 10(5), 4548-4560.