Molecular and Functional Biomarkers
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Molecular and Functional Biomarkers

MFB

Molecular and functional imaging

We are developing new nanoparticles for molecular imaging applications. The group is particularly interested in the potential of these imaging techniques in early diagnosis and molecular characterization of pulmonary vascular remodelling. In our research we seek the application of imaging techniques to describe in detail the efficiency of the pulmonary vascular system to transmit the flow and pressure generated by the heart. This macro-hemodynamic description will be related to an analysis of the final result and aim of the pulmonary circulation, i.e. the pulmonary perfusion. Likewise, we seek to relate this functional evaluation with other imaging tools that allow evaluating the possible vascular damage by studying inflammation and structural local alterations of the pulmonary endothelium.ç

 

Systems biology

We are currently investigating the identification new (early) imaging and systems biology derived biomarkers useful for the diagnosis and monitoring of new treatments of pulmonary vascular diseases such as Pulmonary Hypertension. In common with functional imaging characterisation, profiling of metabolomic, transcriptomic and proteomic alterations of implied cells and affected tissues will reveal new pathogenic mechanisms associated with these diseases. The group is particularly interested in the assessment of metabolic changes associated with cell growth, the structure and function of the right ventricle and cardiovascular coupling biomarkers and signals.

 

Signals biology

Combining different analytic techniques on continuous physiological signals, mainly respiratory and hemodynamics, we are developing new biomarkers for the cardiovascular and pulmonary disease characterization. With a clear translational focus, we want to improve clinical bedside monitoring and improve detection of vascular dysfunction (pulmonary and systemic) at early stage in several scenarios. Our approach is based on a rational combination of technology and physiology.

 

Featured Publications

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation. (Adrover, José M, Aroca-Crevillen, Alejandra, Crainiciuc, Georgiana, Ostos, Fernando, Rojas-Vega, Yeny, Rubio-Ponce, Andrea, Cilloniz, Catia, Bonzon-Kulichenko, Elena, Calvo, Enrique, Rico, Daniel, Moro, María A, Weber, Christian, Lizasoain, Ignacio, Torres, Antoni, Ruiz-Cabello, Jesus, Vázquez, Jesús and Hidalgo, Andrés), In Nature immunology, Nature Publishing Group, volume 273, 2020. 10.1002/mnfr.201900616

Encapsulation of Enzymes in Porous Capsules via Particle Templating. (Zyzin, Mikhail V, Ramos-Cabrer, Pedro and Carregal-Romero, Susana), In Methods in molecular biology (Clifton, N.J.), Springer US, volume 2100, 2020. 10.1007/978-1-0716-0215-7_15

Metabolomic profile of acute respiratory distress syndrome of different etiologies. (Izquierdo-Garcia, José Luis, Nin, Nicolás, Cardinal-Fernández, Pablo, Ruiz-Cabello, Jesus and Lorente, José Angel), In Intensive Care Medicine, Springer Berlin Heidelberg, volume 45, 2019. 10.1007/s00134-019-05634-w

MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles. (Carregal-Romero, Susana, Plaza-García, Sandra, Piñol, Rafael, Murillo, José L, Ruiz-Cabello, Jesus, Padro, Daniel, Millán, Angel and Ramos-Cabrer, Pedro), In Biosensors, Multidisciplinary Digital Publishing Institute, volume 8, 2018. 10.3390/bios8040127

p38γ is essential for cell cycle progression and liver tumorigenesis. (Tomás-Loba, Antonia, Manieri, Elisa, González-Terán, Bárbara, Mora, Alfonso, Leiva-Vega, Luis, Santamans, Ayelén M, Romero-Becerra, Rafael, Rodríguez, Elena, Pintor-Chocano, Aránzazu, Feixas, Ferran, Lopez, Juan Antonio, Caballero, Beatriz, Trakala, Marianna, Blanco, Óscar, Torres, Jorge L, Hernández-Cosido, Lourdes, Montalvo-Romeral, Valle, Matesanz, Nuria, Roche-Molina, Marta, Bernal, Juan Antonio, Mischo, Hannah, León, Marta, Caballero, Ainoa, Miranda-Saavedra, Diego, Ruiz-Cabello, Jesus, Nevzorova, Yulia A, Cubero, Francisco Javier, Bravo, Jerónimo, Vázquez, Jesús, Malumbres, Marcos, Marcos, Miguel, Osuna, Sílvia and Sabio, Guadalupe), In Nature, Nature Publishing Group, volume 15, 2019. 10.1038/s41586-019-1112-8