The research lay in the field of biomaterials and advanced drug carrier systems including the design and the development of polymer and lipid based micro- and nanoscale carriers, their biological evaluation in in vitro cell cultures (toxicity, mechanism of action, intracellular drug release) and also their pharmacokinetic and dynamic impact in vivo (using relevant animal models of the diseases). These micro and nanosystems are prepared using non-toxic, biocompatible and biodegradable biomaterials. Research carried out in this field is mainly applied to cancer, infectious, cardiovascular and neurodegenerative diseases. The main objectives are to target the molecules to their site of action (i.e. cancer cells), to decreases the toxicity of anticancer drugs, to improve the oral absorption of poorly absorbed drugs, to protect fragile molecules like cytokines (for cardiac tissue regeneration) or neurotrophic factors (for brain tissue regeneration) from degradation in the body and to achieve a controlled and sustained release of the entrapped molecules over the time
Nanomedicines and drug delivery
MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics.Yajie Zhang, Miguel García-Gabilondo, Anna Rosell, Anna Roig Pharmaceutics 2020, 12, 16; doi: 10.3390/pharmaceutics12010016
Insights into Preformed Human Serum Albumin Corona on Iron Oxide Nanoparticles: Structure, Effect of Particle Size, Impact on MRI Efficiency, and Metabolization Carlos Moya, Remei Escudero, David C. Malaspina, Maria de la Mata, Jesús Hernández-Saz, Jordi Faraudo, Anna Roig. ACS Appl. Bio Mater. 2019, 2, 7, 3084-3094, doi: 10.1021/acsabm.9b00386
Opportunities of Bacterial Cellulose to Treat Epithelial Tissues.Irene Anton-Sales, Uwe Beekmann, Anna Laromaine, Anna Roig, Dana Kralisch. Curr Drug Targets. 2019;20(8):808-822. doi: 10.2174/1389450120666181129092144.
Parametrizing the exposure of superparamagnetic iron oxide nanoparticles in cell cultures at different in vitro environments. Maria Milla, Si-Ming Yu, and Anna Laromaine. Chemical Engineering Journal 340, (2018) ,173-180doi: 10.1016/j.cej.2017.12.070
In vivo testing of gold nanoparticles using the Caenorhabditis elegans model organism. Laura González-Moragas, Pascal Berto, Clara Vilches, Romain Quidant, Androniki Kolovou, Rachel Santarella-Mellwig, Yannick Schwab, Stephen Stürzenbaum, Anna Roig, and Anna Laromaine. Acta Biomaterialia, April 2017, 53, 598-609. DOI: 10.1016/j.actbio.2017.01.080.
